Graying . . .

 . . . heads . . .

(from http://www.loc.gov/rr/scitech/mysteries/grayhair.html)
". . . Parents often cite having teenagers as the cause of gray hair. This is a good hypothesis, but scientists continue to investigate why hair turns gray. In time, everyone’s hair turns gray. Your chance of going gray increases 10-20% every decade after 30 years. Initially, hair is white. It gets its natural color from a type of pigment called melanin. The formation of melanin begins before birth. The natural color of our hair depends upon the distribution, type and amount of melanin in the middle layer of the hair shaft or cortex.

Hair has only two types of pigments: dark (eumelanin) and light (phaeomelanin). They blend together to make up the wide range of hair colors.

Melanin is made up of specialized pigment cells called melanocytes. They position themselves at the openings on the skin’s surface through which hair grows (follicles). Each hair grows from a single follicle. . . the hair follicle has a “melanogentic clock” which slows down or stops melanocyte activity, thus decreasing the pigment our hair receives. This occurs just before the hair is preparing to fall out or shed, so the roots always look pale.

Moreover, Dr. Tobin suggests that hair turns gray because of age and genetics, in that genes regulate the exhaustion of the pigmentary potential of each individual hair follicle. This occurs at different rates in different hair follicles. . ."

What do you think?

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OHO's "Ocean City Ditty," the CD single is now available at http://www.cdbaby.com/cd/oho4
(and, if you're in town, at Trax On Wax on Frederick Rd. in Catonsville, MD) OHO is Jay Graboski, David Reeve & Ray Jozwiak.  Please Visit http://www.ohomusic.com 


My latest solo offering, Just More Music by Ray Jozwiak, featuring original, instrumental piano music will be released April 7, 2014  Just More Music by Ray Jozwiak

(To Access all Ray Jozwiak - Gonzo Piano music you can copy-and-paste this URL directly to
your browser:  http://http://www.cdbaby.com/Artist/RayJozwiak)

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If only. . .

. . . or should I ask "when only"?

The New York Times
Sept. 13, 2011
". . . A year ago, when chemotherapy stopped working against his leukemia, William Ludwig signed up to be the first patient treated in a bold experiment at the University of Pennsylvania. Mr. Ludwig, then 65, a retired corrections officer from Bridgeton, N.J., felt his life draining away and thought he had nothing to lose.

Doctors removed a billion of his T-cells — a type of white blood cell that fights viruses and tumors — and gave them new genes that would program the cells to attack his cancer. Then the altered cells were dripped back into Mr. Ludwig’s veins.

At first, nothing happened. But after 10 days, hell broke loose in his hospital room. He began shaking with chills. His temperature shot up. His blood pressure shot down. He became so ill that doctors moved him into intensive care and warned that he might die. His family gathered at the hospital, fearing the worst.

A few weeks later, the fevers were gone. And so was the leukemia.

A number of research groups have been trying to do this, but the T-cells they engineered could not accomplish all the tasks. As a result, the cells’ ability to fight tumors has generally been temporary.

The University of Pennsylvania team seems to have hit all the targets at once. Inside the patients, the T-cells modified by the researchers multiplied to 1,000 to 10,000 times the number infused, wiped out the cancer and then gradually diminished, leaving a population of “memory” cells that can quickly proliferate again if needed.

The researchers said they were not sure which parts of their strategy made it work — special cell-culturing techniques, the use of H.I.V.-1 to carry new genes into the T-cells, or the particular pieces of DNA that they selected to reprogram the T-cells. . ."

Hell of a thing, don't you think?!





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