Showing posts with label experiment. Show all posts
Showing posts with label experiment. Show all posts

Friday, June 28, 2013

Dark. . .

. . . Side. . .

. . . NOT Pink Floyd. . .

Oho guitarist and several Baltimore underground talents WERE. . . The Dark Side

(from www.ohomusic.com)
". . . Evolving out of the infamous OHO, Dark Side began as a studio experiment in late 1977. While 70s OHO developed from a weirdly sinister and oddball Ubu/Beefheart approach, Dark Side had a preoccupation with "updated-for-the-80s" 60s pop, manifested in the teen-drama lyrics, neo-Spector production and delightfully squeaky Farfisa organ fills.

The original 6-man line-up recorded 2 EP's in January ("Wholesale Diamonds") and September ("Damaged Goods") 1978 respectively. Thanks to the intervention of Ful Treatment keyboardist, Ray Jozwiak, this incarnation of the band made their only live appearance on a local television program (Baltimore At Ten) in the spring of '78.

The band, reduced then to a quartet, began to play live at the infamous Marble Bar on Franklin St. in downtown Baltimore and The Odd Fellows Hall in Towson, MD. Due to the opportunities afforded by regular gigging, the Side discovered its identity and began to shape its own sound.

An LP (Rumors in Our Own Time/Legends in Our Own Room) was produced with USE guitarist, Paul Rieger, during 1979 and on into early 1980. Joining shortly thereafter, drummer David Reeve (OHO's current drummer) helped the band integrate its various influences and explore a range of music that encompassed 60s R&B, punk, humorous pop, garage and gothic-progressive rock. The band defied easy categorization, living up to the notoriety that Dark Side members Jay & Jeffrey Graboski, Mark O'Connor and David Reeve established in 70s OHO (1973-1977). Dark Side remained true to a music that was stripped down and driving, yet capable of an emotional subtlety not usually associated with bands of their ilk. . . "


Jay's composition You Should Envy Me, originally by The Dark Side, is redone here by the current lineup of OHO, Jay Graboski, David Reeve and me (Ray Jozwiak) . . .




You Should Envy Me
written by John P. Graboski
performed by Oho (rehearsal recording)





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Wednesday, September 14, 2011

If only. . .

. . . or should I ask "when only"?

The New York Times
Sept. 13, 2011
". . . A year ago, when chemotherapy stopped working against his leukemia, William Ludwig signed up to be the first patient treated in a bold experiment at the University of Pennsylvania. Mr. Ludwig, then 65, a retired corrections officer from Bridgeton, N.J., felt his life draining away and thought he had nothing to lose.

Doctors removed a billion of his T-cells — a type of white blood cell that fights viruses and tumors — and gave them new genes that would program the cells to attack his cancer. Then the altered cells were dripped back into Mr. Ludwig’s veins.

At first, nothing happened. But after 10 days, hell broke loose in his hospital room. He began shaking with chills. His temperature shot up. His blood pressure shot down. He became so ill that doctors moved him into intensive care and warned that he might die. His family gathered at the hospital, fearing the worst.

A few weeks later, the fevers were gone. And so was the leukemia.

A number of research groups have been trying to do this, but the T-cells they engineered could not accomplish all the tasks. As a result, the cells’ ability to fight tumors has generally been temporary.

The University of Pennsylvania team seems to have hit all the targets at once. Inside the patients, the T-cells modified by the researchers multiplied to 1,000 to 10,000 times the number infused, wiped out the cancer and then gradually diminished, leaving a population of “memory” cells that can quickly proliferate again if needed.

The researchers said they were not sure which parts of their strategy made it work — special cell-culturing techniques, the use of H.I.V.-1 to carry new genes into the T-cells, or the particular pieces of DNA that they selected to reprogram the T-cells. . ."

Hell of a thing, don't you think?!





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